UpSurgeOn, a deep-tech start-up specialising in the development of advanced technologies to enhance surgical skills using hybrid simulation and digital platforms, has announced that it has closed a €5 million investment round.
The transaction is led by CDP Venture Capital, with the participation of Simest (through resources from the F.394/81 – Equity Investments and Venture Capital Section, managed under an agreement with the Ministry of Foreign Affairs and International Cooperation), Deep Blue Ventures (DBV), the deep-tech venture capital fund managed by Deep Ocean Capital, Azimut Libera Impresa, with its own venture capital funds, and FBH.
UpSurgeOn, founded by two Italian neurosurgeons and comprising a team of surgeons, engineers and digital creators, develops advanced, hyper-realistic multidisciplinary simulation technologies based on a hybrid approach that integrates virtual reality, advanced physical models and digital platforms, with the aim of making surgical training more accessible, sustainable and accurate worldwide. In just a few years, the company has gained the endorsement of numerous international scientific bodies, collaborates with some of the world’s leading medtech companies and has marketed its technologies in over 110 countries. Applications now range from cranial and spinal neurosurgery to plastic surgery, otolaryngology and orthopaedics, with continuous expansion into new disciplines and a growing presence in the scientific literature.
The funds raised will support the company’s global expansion, the enhancement of its proprietary platforms across new surgical specialities, and the acceleration of research and development activities in the field of advanced psychomotor enhancement in surgery. The aim is to reinforce the vision of a new generation of surgeons trained on the basis of objective performance assessments, certified metrics and ever-higher standards of patient safety, with a significant impact on the sustainability of healthcare systems and the reduction of insurance costs associated with surgical practice.
This new investment follows the €3 million funding round secured in 2022 with the support of Guala Dispensing, which marked a key milestone in accelerating the company’s technological and industrial development. Over the years, UpSurgeOn has also secured several national and international grants to support its research and innovation activities, further strengthening its position within the European deep-tech landscape.
Federico Nicolosi, CEO and founder of UpSurgeOn (pictured here with fellow co-founder Giannantonio Spena), comments: “We are extremely proud and motivated by this significant funding round, and proud to be working with partners of great vision. We will continue to expand our global presence whilst maintaining a clear focus on the practical needs of surgery: UpSurgeOn was born out of our ability to listen to a complex ecosystem, without ever forgetting that the ultimate goal of our work is the patient’s well-being.”
Mario Scuderi, Head of the Evolution Fund at CDP Venture Capital, says: “Investing in UpSurgeOn means supporting an exceptional team with a unique blend of cross-disciplinary skills.” “We are convinced that this platform can have a tangible impact on patient safety worldwide: ensuring surgeons are increasingly well-trained means improving people’s lives. In a sector where access to high-quality training remains deeply unequal across different geographical areas, UpSurgeOn has the potential to democratise surgical excellence on a global scale.”
“UpSurgeOn is a concrete example of how deep tech can transform scientific research into high-impact industrial applications. The ability to integrate physical simulation, digital platforms and virtual reality into a single technological ecosystem opens up new possibilities in advanced surgical training. “At Deep Blue Ventures, we support businesses that do more than simply innovate a product; they redefine industry standards and infrastructure. In the case of UpSurgeOn, this means helping to improve the quality of medical training and, ultimately, patient safety on a global scale,” says Domenico Nesci, CEO of Deep Ocean Capital and partner at Deep Blue Ventures.
“As Azimut Venture Capital, we are delighted to support UpSurgeOn in its mission to revolutionise medical training. Their advanced simulation technology aims to bridge the gap between theory and practice by providing surgeons with a hyper-realistic environment. “We believe that Federico Nicolosi, CEO and co-founder, and as a former surgeon, is the right person to drive the development of technology to support patients,” adds Guido Bocchio, head of venture capital at Azimut Libera Impresa.
Vera Veri, Chief Investment Officer at Simest: “With this investment, Simest is supporting the international expansion of UpSurgeOn, an Italian deep-tech company that is bringing innovative solutions for advanced surgical training to global markets.” “The technological approach developed by the company, which combines hybrid simulation, physical models and digital platforms, meets a growing international demand for training tools that are increasingly effective, accessible and based on objective metrics. Initiatives such as this help to strengthen the presence of high-tech Italian companies within the world’s leading scientific and medical ecosystems, promoting the spread of Italian expertise and innovation.”
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